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Senior Scientist Analytical Development LCMS

date posted 11/11/2022
contract type Full time
job id R2655490
location Waltham, MA;

SUMMARY:

Sanofi is seeking a motivated analytical research and development scientist to join the Analytics group located in Waltham, MA. The Analytics group combined with Synthesis Development, Biopharmacy and Early Formulation Development constitutes the Early Development organization in the US (EDUS) which provides the CMC expertise to advance projects from late-stage research through early clinical development up to Phase 2 clinical trials. As part of the Global CMC Development organization, EDUS is striving to become an industry leader in the development of transformative medicines.

NOTE: This position will be moving to Cambridge, Massachusetts, by the end of 2022**

Reporting to the Senior Director of Analytics in Waltham, the scientist will contribute to and/or be responsible for the analytical method development, analyses, characterization of research and development compounds, process impurities and degradants. 

KEY RESPONSIBILITIES:

  • Collaborate with Formulation Development, Biopharmacy, Synthesis Development, Medicinal Chemistry, Process Chemistry and Process Engineering groups, as well as scientists from various therapeutic areas to support pre-development and early development activities

  • Work closely with scientists at the Integrated Drug Discovery (IDD) to develop assays for compound screening and optimization. 

  • Develop assays and perform analysis of selected biomarkers to support drug development programs.

  • Develop methods and perform experiments for the identification and quantification of process impurities and degradants by LCMS

  • Develop and implement platform analytical methods to support process chemistry and process engineering and provide local analytical support as needed

  • Develop LCMS based assays to support compound screening and optimization

  • Develop methods and perform analysis of targeted biomarkers

  • Promote compliance on Health, Safety and Environment in the analytical laboratories

BASIC QUALIFICATIONS:

  • PhD in Analytical Chemistry or related sciences with a minimum of 4 years of related experience , or Master's degree with a minimum of 8 years of experience within the pharmaceutical/biotech industry

  • Demonstrated experiences in supporting process chemistry and process development teams in impurity identification and impurity tree determination

  • Familiarity with the operation of HRAMS instruments and UHPLC systems

  • Broad knowledge of LC/MS/MS applications and other separation technologies complementary to LCMS

  • Ability to work in a cross-functional environment

  • Excellent communication skills

PREFERRED QUALIFICATIONS:

  • Knowledge of QbD concepts, specification setting, and cGMP, with experience in contributing to regulatory submission

  • In-depth understanding of separation principles of liquid chromatography and ion mobility

  • In-depth understanding of the principles of tandem mass spectrometry and state-of-the-art ion dissociation techniques

  • Demonstrated ability to solve complex problems with advanced LC/MS techniques

  • Prior experiences in the development of LCMS methods to support biochemical assays

  • Ability to handle multiple assignments

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society. 

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.  

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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