Job Overview:

The 2024 Co-Op will work in the upstream process development group of the drug substance function in Specialty Care Manufacturing Science and Analytical Technology (MSAT). The co-op will work in a laboratory setting on a project related to on-line monitoring of mammalian cell culture using Raman spectroscopy for perfusion process development. This position is 6 months on a full-time basis July 2024 – December 2024.

The drug substance function within global Manufacturing Science & Analytical Technology (MSAT) is the owner of Life Cycle Management (LCM) of DS Processes within Sanofi biologics manufacturing network. We deliver innovative, robust, and cost-effective next generation processes and provide commercial manufacturing support. The function is responsible for tech transfer activities including process fit-gap assessment, process validation, prepare dossier sections, & PAI support to enable launch of new and LCM products. Our expansive portfolio covers 17 products, 5 modalities, 3 expression systems within 12 internal and external global sites in US and EU. We will be supporting launch of 20 new products in next 5 years including monoclonal and multi-specific antibodies, fusion proteins, antibody-drug conjugates, synthorins and nanobodies. In recent years we have successfully established second-generation manufacturing process with a continuous process platform. We are pursuing future innovations such as digital labs, factories of future and advanced analytics-based process understanding and control.

Responsibilities:

In this project co-op student will  

• Operate perfusion bioreactors  

• collect and run cell culture samples in multiple instruments for cell counting and metabolites 

• set up, maintain and troubleshoot Raman equipment (transmitter, probes), etc. 

• collaborate with SMEs to build the models using online Raman data 

• Update the team during regular meeting and give a presentation at the end of the project  

Basic Qualifications:

• Pursuing a Bachelor’s (sophomore year or higher) or Master’s degree in Chemical Engineering, Biochemistry, Biotechnology, or related discipline.

Preferred Qualifications:

• Experience in a biotechnology or pharmaceutical industry laboratory setting

• Basic understanding of cell culture processes and bioreactor operations 

• Experience in statistical analysis, preferably experience using statistical software JMP or similar 

• Experience in data-driven modeling  

• Experience in scripting and familiarity with process controllers like MFCS and DELTA-V 

• Strong technical writing and presentation skills

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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