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Postdoctoral Fellow, Non-Viral Gene Therapy, Genomic Medicine Unit

date posted 09/26/2021
contract type Full time
job id R2611405
location Framingham, Massachusetts

Postdoctoral Fellow, Non-Viral Gene Therapy, Genomic Medicine Unit

Waltham, MA

The Genomic Medicine Unit is seeking a highly motivated Postdoctoral Fellowship candidate that will help build innovation in the area of tissue-targeted lipid nanoparticle delivery.

The successful candidate will work transversally with members of various research groups including non-viral research, large molecule research, molecular biology, and bioinformatic teams to optimize delivery of DNA cargo and nanoparticle formulations to specific tissues. Participation in this project will provide the candidate a tangible opportunity to contribute to development of novel genomic medicine approaches for rare diseases with unmet need. The candidate will also join the Global Sanofi Postdoctoral program and community in which there are opportunities for networking, learning, career development and mentorship.  The Global Sanofi Postdoctoral program offers several activities, including ‘Lunch & Share’, a forum for data sharing and feedback, “Lunch & Learn” with presentations from subject matter experts across Sanofi, ‘Fireside Chats’ comprising career stories and advice from Sanofi leadership, and an annual Postdoctoral symposium which provides the opportunity for fellows to showcase their research and themselves to the entire Global R&D Organization. 

Key Responsibilities:

  • Establish creative strategies for delivering lipid nanoparticles that target specific tissues with an initial focus on using peptides and antibodies
  • Develop analytical assays for determining LNP distribution in tissues
  • Develop approaches to optimize DNA cargo delivery and establish approaches for testing delivery of cargo in cells and tissues
  • Collaborate with wet-lab and computational scientific teams and help the group champion projects from discovery to early clinical development.

Required Qualifications:

  • PhD in Biology or Chemistry
  • Working knowledge with lipid nanoparticles and nucleic acid delivery
  • Ability to develop and troubleshoot experimental procedures
  • Ability to perform animal research
  • The ability to manage multiple projects in parallel, communicate clearly and effectively and build open and collaborative relationships with scientists from multiple groups is essential
  • Strong interested in biology, medicine and caring for developing novel therapeutic intervention strategies for patients with unmet disease conditions
  • Must have permanent US work authorization

Preferred Qualifications:

  • Knowledge of antibody structures
  • Prior experience with peptide conjugation
  • Prior experience with in vivo studies
  • Proficiency in biostatical methods

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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