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A Range of Possibilities

Scientist, Purification Development

date posted 09/24/2021
contract type Full time
job id R2604101
location Framingham, Massachusetts

Position Overview:

Purification Process Development (part of Sanofi R&D) is responsible for development, scale-up, transfer, and characterization of purification processes for clinical and commercial manufacturing of therapeutic proteins from the mammalian production platform. In addition, the department develops next-generation bioprocessing and process development technologies such as integrated and continuous bioprocessing, high throughput process development, and mechanistic modeling of bioprocesses. The department also works to support a global purification network and update our purification platform.

Key Responsibilities:

We are looking for candidates for the position of Scientist. This individual should be able to use scientific principles and professional practices to creatively and practically solve a wide range of problems, while ensuring the highest standards of safety, environmental and regulatory compliance are maintained in the workplace. Responsibilities include:

  • Leading the development of robust downstream unit operations and processes that can be scaled to pilot, clinical, and commercial manufacturing scales.

  • Leading the examination of novel purification technologies for manufacturing and process development.

  • Developing areas of specific technical expertise and training and guiding others in those areas.

  • Representing the department in cross-functional and/or cross-site interactions.

  • Preparing internal technical reports and externally presenting and/or publishing technology advancements.

Basic Qualifications:

  • PhD. in Chemical Engineering, Bioengineering, or related discipline or Master's degree with a minimum of 4 years of relevant industry experience or Bachelor's degree with a minimum of 6 years of relevant industry experience.

  • Ability to work as part of a diverse cross-functional team.

  • Excellent oral and written communication skills.

Preferred Qualifications:

  • An understanding of scientific and engineering principles and techniques used in the unit operations for production of protein therapeutics such as:

    • AKTA or automated protein purification chromatography.

    • Tangential flow filtration or UF/DF.

    • Virus clearance and inactivation.

    • Filtration unit operations at various scales.

  • Strong understanding of the principles of Quality by Design and ability to apply DOE to downstream development.

  • Knowledge of basic analytical tools such as spectrophotometry, ELISA, HPLC, and SDS-PAGE.

  • Self-motivated, organized, and detail-oriented.

  • High level of scientific curiosity.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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